Guerenne L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P, Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera M-E, Pla M, Fenaux P, Padua RA, Chomienne C, Krief P. GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways. J Hematol Oncol. 9: 5, 2016. PMID: 26817437 Download

Le Pogam C, Patel S, Gorombei P, Guerenne L, Krief P, Bernasconi E, Tekin N, Sicre F, Schlageter M-E, Chopin M, Mathews V, West RR, PLA M, Fenaux P, Chomienne C, Padua RA. DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies. Oncotarget 6:32:494-508, 2015. PMID: 26378812 Download

Patel S, Guerenne L, Gorombei P, Omidvar N, Schlageter M, Alex AA, Ganesan S, West R,  Adès L, Mathews V, Krief P, Pla M, Fenaux P, Chomienne C, Padua RA. PVAX14-mediated add-on immunotherapy combined with arsenic trioxide and all-trans retinoic acid (ATO+ATRA) targeted therapy effectively increases survival of APL mice. Blood Cancer Journal, Dec 11;5:e374. doi: 10.1038/bcj.2015.102 PMID: 26657197 Download

Supplementary Materials for pVAX14DNA-mediated add-on immunotherapy combined with arsenic trioxide and all-trans retinoic acid (ATO+ATRA) targeted therapy effectively increases survival of APL mice- Blood Cancer Journal (2015) Download

Beurlet S, Omidvar N,Gorombei P, Krief P, Le Pogam C, Setterblad N, de la Grange P, Leboeuf C, Janin A,Noguera M-E, Hervatin F, Sarda-Mantel L, Konopleva M, Andreeff M, Tu A, Fan AC, Felsher DW, Whetton A, Pla M, West R, Fenaux P, Chomienne C, Padua RA. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. Blood 122: 2864-2876, 2013. PMID: 23943652 Download

Pokorna K, Chopin M, Le Pogam C, Balitrand N, Reboul M, Cassinat B, Chomienne C, Padua RA, Pla M. Tracking of oncogene positive cells in preclinical models: biomarker of long term drug efficacy. Molecular and Cellular Probes 27:1-5, 2013. PMID: 22906630 Download

Tracking the extramedullary PML-RAR-positive cell reservoirs in a preclinical model: Biomarker of long-term drug efficacy- Elsevier (2012) Download

Furugaki K, Pokorna K, Le Pogam C, Aoki M, Reboul M, Bajzik V, Krief P, Janin A, Noguera ME, West R, Charron D, Chomienne C, Pla M, Moins-Teisserenc H, Padua RA. DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model. Blood 15:653-6, 2010. PMID: 19965687 Download

Omidvar N, Kogan S, Beurlet S, Le Pogam C, Janin A, West R, Noguera ME, Reboul M., Soulie A., Le Bœuf C,  Setterblad N, Felsher D, Lagasse, E, Mohamedali A, Thomas NS, Fenaux P, Fountenay M,  Pla M, Mufti GJ, Weissmann I, Chomienne C, Padua RA. BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia. Cancer Research 67:11657-67, 2007. PMID: 18089795 Download

Rassool F, Gaymes T, Omidvar N, Brady N, Pla M, Reboul M, Lea N, Chomienne C, Thomas NS, Mufti GJ, Padua RA. Reactive oxygen species, DNA damage and error-prone repair: a model for genomic instability with progression in myeloid leukemia? Cancer Research 67:8762-71, 2007. PMID: 17875717 Download

Robin M, Andreu-Gallien J, Schlageter M-H, Bengoufa D, Guillemot I,Pokorna K, Robert C, Larghero J, Rousselot P, Raffoux E, Dombret H, Fenaux P, Pla M, Charron D, Padua RA, Chomienne C. Frequent antibody production against RARa in both APL mice and patients. Blood 108:1972-1974, 2006. PMID: 16728697  Download

Gaymes TJ, Padua RA, Pla M,  Orr S, Omidvar N, Chomienne C, Mufti GJ, Rassool F. Histone Deacetylase Inhibitors (HDI) cause excessive DNA Damage in leukemia cells: A Mechanism for leukemia-specific HDI Dependent Apoptosis? Molecular Cancer Research, 4 :563-573, 2006. PMID: 16877702 Download

PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia- Nature Medicine (2003) Download

Cancer Vaccine Targets Leukemia- Nature Medicine (2003) Download

Colombani T, Haudebourg T, Decossas M, Lambert O, Ada Da Silva Grace, Altare F and Pitard B. Lipidic Aminoglycoside Derivatives : a New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation. AdvSci (Weinh) (2019) 6:1900288. Download

Lindsay KE, Bhosle SM, Zurla C,  Beyersdorf J, Rogers KA, Vanover D, Xiao P, Araínga M, Shireff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ. Visualization of early events in mRNA vaccine delivery in non-human primates via PET/CT and near-infrared imaging. Nat Biomed Eng. (2019) 3:371-380 Download

Desigaux, L., Sainlos, M., Lambert, O., Chèvre, R., Letrou-Bonneval E., Lehn, P., Lehn, J.M. and Pitard B. Self-assembled lamellar complexes formed by lipidic aminoglycoside derivatives and siRNA promote efficient RNA interference. Proc. Natl. Acad. Sci. USA (2007) 104, 16534-16539 Download

Pitard, B., Oudrhiri, N., Vigneron, J.P., Hauchecorne, M., Aguerre, O., Toury, R., Airiau, M., Ramasawmy, R., Scherman, D., Crouzet, J., Lehn, J.M. and Lehn, P. Structural characteristics of supramolecular assemblies formed by guanidinium-cholesterol reagents for gene transfection. Proc. Natl. Acad. Sci. USA (1999) 92, 2621-2626. Download

Pitard, B., Aguerre, O., Airiau, M., Lachagès, A.M., Boukhnikachvili, T., Byk, G., Dubertret, C., Herviou, C., Scherman, D., Mayaux, J.F. and Crouzet, J. Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer. Proc. Natl. Acad. Sci. USA (1997) 94, 14412-14417. Download

Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging. Lindsay KE, Bhosle SM, Zurla C, Beyersdorf J, Rogers KA, Vanover D, Xiao P, Araínga M, Shirreff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ. Nat Biomed Eng. 2019 May;3(5):371-380. doi: 10.1038/s41551-019-0378-3. Epub 2019 Apr 1 PMID: 30936432 Download